Neural dynamics during anoxia and the "wave of death".

Neural dynamics during anoxia and the "wave of death".

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Recent experiments in rats have shown the occurrence of a high amplitude slow brain wave in the EEG approximately 1 minute after decapitation, with a duration of 5-15 s (van Rijn et al, PLoS One 6, e16514, 2011) that was Goldenrod presumed to signify the death of brain neurons.We present a computational model of a single neuron and its intra- and extracellular ion concentrations, which shows the physiological mechanism for this observation.The wave is Medication Management caused by membrane potential oscillations, that occur after the cessation of activity of the sodium-potassium pumps has lead to an excess of extracellular potassium.

These oscillations can be described by the Hodgkin-Huxley equations for the sodium and potassium channels, and result in a sudden change in mean membrane voltage.In combination with a high-pass filter, this sudden depolarization leads to a wave in the EEG.We discuss that this process is not necessarily irreversible.